产品货号：
Z15083
中文名称：
Cyclin E1/CCNE1抗体
英文名称：
Anti-Cyclin E1/CCNE1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cyclin E1/CCNE1 Antibody |
| 指标别名 | CCNE;CCNE1;cyclin E1;G1/S specific cyclin E1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | CCNE1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Cyclin E1/CCNE1 recombinant protein (Position:R3-A386). |
| 实际分子量 | 47KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.It is mapped to 19q12.The protein encoded by this gene belongs to the highly conserved cyclin family,whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.This cyclin forms a complex with and functions as a regulatory subunit of CDK2,whose activity is required for cell cycle G1/S transition.This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase.Overexpression of this gene has been observed in many tumors,which results in chromosome instability,and thus may contribute to tumorigenesis.This protein was found to associate with,and be involved in,the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus),which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. |
| Uniprot ID | P24864 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | cyclin E1 |
| 蛋白名全称 | G1/S-specific cyclin-E1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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